General unknown screening by ion trap LC/MS/MS
(Book - Regular Print)

"Work was accomplished under approved task AM- AM-B-05-TOX-204."--P. i.

"April 2010."

"DOT/FAA/AM-10/8."

Includes bibliographical references.

Final report.

"During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. The first, and perhaps most important, step in the analysis process is the initial screening of biological specimens for illicit, medically prescribed, and over-the-counter compounds that may be present and could have been the cause of the accident. Currently, our General Unknown Screening (GUS) procedure involves both gas chromatography/mass spectrometry (GC/MS), liquid chromatography/diode array detection (LC/DAD) and fluorescence detection techniques. Both techniques have inherent limitations that prevent the detection of certain types of compounds. LC/DAD, however, is more limited due to poor sensitivity and specificity. Therefore, our laboratory developed and validated an LC/MS/MS procedure that provides far superior sensitivity and specificity to that of LC/DAD. The combination of GC/MS with LC/MS/MS will allow for the detection of more compounds at lower concentrations than our current techniques."--P. i.

Also available online in PDF from the Aerospace Medicine Technical Reports Web site.

Sponsored by the Office of Aerospace Medicine, Federal Aviation Administration; performed by the FAA Civil Aerospace Medical Institute.